Calorie for calorie: what the ultra-processed-diet trial found in 43 men — and the published dispute over what it shows

ultra processed foods green and red labeled plastic pack

A crossover trial matched calories and macronutrients between ultra-processed and unprocessed diets in 43 young men. Fat mass rose about 1 kg on the ultra-processed diet; testosterone and sperm changes were non-significant trends. Two published critiques contest the interpretation.

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Why do GLP-1 weight-loss drugs work differently for different people?

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Two people can take the same GLP-1 weight-loss drug, follow the same instructions, and get completely different results. Three publications in the same week September 2026 converge on one bottom line: people's responses to these medicines vary widely, and much of that variation — like part of the drugs' heart protection — remains unexplained.

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What Happens When People Stop Weight-Loss Medications

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Pooled evidence from 37 studies and two withdrawal trials: about 0.4 kg regained per month after stopping (0.8 kg after semaglutide or tirzepatide), most lost weight typically returning within about a year, with cardiometabolic gains fading alongside — plus what remains projected, not measured. About 0.4 kg (about 0.9 lb) regained per month after stopping weight-loss medications — 0.8 kg (about 1.8 lb) after semaglutide or tirzepatide — and cardiometabolic gains fade too.

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